What Are Common Targeted Therapies Used in Breast Cancer
By Cancer Clinical Trial Specialist

What Are Common Targeted Therapies Used in Breast Cancer

There are many targeted therapies used in breast cancer that depend on the specific mutations present in the patient. Targeted therapies locate and attack specific abnormalities or characteristics within the DNA of cancerous cells. These therapies can be administered through an IV or taken orally so they can work throughout the body. This is advantageous for patients with metastatic cases because some treatments can only be used for localized disease. Targeted therapies also avoid healthy cells, which in some cases, leads to less significant symptoms and side effects.

To identify which mutations are present in a cancer patient, a form of genetic testing needs to be performed. A biopsy will be taken of the patient’s tumor, then sent to a laboratory to analyze the results. They will detect any abnormalities within the DNA of the cancerous cells, like excess proteins. If the results come back that you do have a gene mutation, you may be eligible for a targeted therapy.

Targeted Therapies Used in Breast Cancer

The targeted therapy drug used for breast cancer patients depends on the extent of their disease, whether or not it has metastasized, and which gene mutation is present. The following drugs are used in the different types of breast cancer.

Targeted therapies for metastatic HER2-positive cancer:

  • Trastuzumab (Herceptin)
  • Pertuzumab (Perjeta)
  • Ado-trastuzumab emtansine (Kadcyla)
  • Neratinib (Nerlynx)
  • Margetuximab-cmkb (Margenza)
  • Lapatinib (Tykerb)

Targeted therapies for HER2-negative breast cancer:

  • Palbociclib (Ibrance)
  • Ribociclib (Kisqali)
  • Abemaciclib (Verzenio)
  • Everolimus (Afinitor, Zortress).
  • Alpelisib (Piqray)

Targeted therapy for triple negative breast cancer:

  • Sacituzumab govitecan-hziy (Trodelvy)

Targeted therapies for the BRCA1 or BRCA2 mutations:

  • Talazoparib (Talzenna)
  • Olaparib (Lynparza)

The side effects for targeted therapies can vary for each patient and depends on the specific drug used for treatment. Some patients will experience mild symptoms while others have more serious side effects. Some common side effects are shortness of breath, leg swelling, and fatigue. Some more serious side effects include heart damage, liver problems, and severe diarrhea. Speak with your doctor if you are interested in learning more about targeted therapies to see if you are eligible.

Gene Mutations in Breast Cancer

The most common genetic mutation for breast cancer is BRCA1 and BRCA2, which are hereditary. Either one is found in roughly 20 percent of all breast cancer cases. Other common mutations found in breast cancer include:

  • ATM
  • FGFR
  • HER2
  • PIK3CA
  • TP53
  • PTEN
  • CHEK2
  • STK11
  • PALB2

There are many other mutations that can be found in breast cancer and other cancer types. Genes are responsible for different functions of cells and testing positive for a mutation can reveal more about your prognosis and what drives the growth of the tumor. Your doctor also might be able to tell which treatment options you will be resistant to, or more responsive to. Targeted therapies for breast cancer patients are also available in clinical trials for patients to enroll in. The eligibility criteria can be specific and is different for each trial, so talk with your doctor to see if clinical trials could benefit your case.




Covid Live Event
By Cancer Clinical Trial Specialist

COVID-19 and Cancer Patients: What You Should Know

The Facebook live event, COVID-19 and Cancer Patients: What You Should Know, was hosted by Massive Bio on January 13, 2021. The live event featured interviews about COVID-19 and its effect on cancer patients from Massive Bio medical experts. Guests included Massive Bio’s Co-founder and Chief Medical Advisor, Dr. Arturo Loaiza-Bonilla, MD; Chief Nursing Officer, Kristin Johnston, BSN, RN; and host Chief Customer Delivery Manager, Stephanie Tran.

Read more “COVID-19 and Cancer Patients: What You Should Know”

Advanced Breast Cancer With Genomic Testing
By Cancer Clinical Trial Specialist

Advanced Breast Cancer with Genomic Testing

Advanced Breast Cancer With Genomic Testing Fast Facts
Advanced Breast Cancer With Genomic Testing Fast Facts
  1. Inherited genetic mutations account for up to 10% of all breast cancers.
  2. BRCA 1/2 mutations are the most common and most studied inherited genetic mutation in breast cancer. Approximately 1 in 400 women have a BRCA gene mutation. Women with one of these mutations have up to a 7 in 10 chance of getting breast cancer in their lifetime.
  3. FGFR stands for Fibroblast Growth Factor Receptor. Around 15% of breast cancers have a FGFR1 gene mutation.
  4. Many women with breast cancer show no symptoms early in the disease, making routine screening important. Self-breast exams and mammograms are the most common screening measures.
  5. The most common symptoms in breast cancer are a lump or swelling in the breast or underarm that doesn’t go away, a flat or indented area on the breast, changes in nipple appearance or feeling, and unusual nipple discharge.
Advanced Breast Cancer with Genomic Testing Hopeful Highlights
Advanced Breast Cancer with Genomic Testing Hopeful Highlights
  1. Many breakthroughs in preventative treatments for breast cancer have been made over the past 20+ years including the approval of Raloxifene in 2006!
  2. There are over 600 breast cancer charities currently active in the United States. An estimated 6 billion dollars is raised each year for breast cancer! People care about this disease and want to help. Reach out to your local organizations!
  3. The death rate for breast cancer has been continuously dropping by an average of 1.4% per year over the past 10 years!

More Details: Genomic Testing for Breast Cancer

Free Matching to Cancer Clinical Trials

  • Your match report contains a detailed list of cervical cancer clinical trials that you may be eligible to enroll in to receive unique and nonconventional treatment. Standard treatment is not the only option.
  • A patient advocate will review your report with you to answer any questions or concerns you may have and assist with enrollment if you decide to move forward with a trial.
  • There’s no need to travel to a clinical trial site until the enrollment process is complete.

Our number one priority is creating positive outcomes for cancer patients. Let us help you today.

Triple Negative Breast Cancer
By Cancer Clinical Trial Specialist

Triple Negative Breast Cancer

Triple negative breast cancer is a type of breast cancer that does not have three of the most common types of receptors associated with breast cancer present in the cancer tumor. These receptors include a protein known as human epidermal growth factor receptor 2 (HER2), estrogen receptors (ER), and progesterone receptors (PR). When these receptors are present in the breast cancer, doctors have the ability to use targeted therapy to help destroy cancer cells. However, with triple negative breast cancer (TNBC), this is not a capability because these hormone receptors are not driving the growth of

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Breast Cancer Diet Plan
By Cancer Clinical Trial Specialist

Breast Cancer Diet Plan

A breast cancer diet plan could help patients ensure they get the nutrients they need while going through treatment. Often, the side effects of breast cancer treatment make eating full, nutritious meals feel like an impossible task. With side effects such as nausea, vomiting, and mouth sores, it can be hard to want to eat a meal. However, proper nutrition will help patients’ bodies heal from treatment, maintain a healthy body weight, and avoid loss of muscle mass. Establishing a diet plan could help patients meet proper nutrition needs despite the struggles associated with eating.

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Breast Cancer Clinical Trials
By Cancer Clinical Trial Specialist

Breast Cancer Clinical Trials

Breast cancer clinical trials help doctors and scientists look for better ways to treat and screen for breast cancer. Clinical trials are carefully designed research studies that utilize volunteers to find new treatments, study different combinations of treatments, and research new approaches to treatments like radiation therapy or surgery. Participants of clinical trials often get access to the treatments being studied years before the public.

Reasons for participating in clinical trials differ between patients. Some people find that

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Breast Cancer Signs And Symptoms
By Cancer Clinical Trial Specialist

Breast Cancer Signs and Symptoms

Whether you or someone you love has been affected by breast cancer, understanding what to expect, as well as the breast cancer signs and symptoms, might help you cope.

Women are more likely than men are to develop most breast cancers. The different types of breast cancer include ductal carcinoma in situ, invasive ductal carcinoma, inflammatory breast cancer, and metastatic breast cancer. Catching these breast cancer signs at an earlier stage, is important for having the highest survival chance possible.

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